Mood-improving medication Crossword Clue

We have the 4-letter answer for Mood-improving medication crossword clue, last seen in the Missing Letter Crossword February 22, 2026 puzzle. This answer will help you finish the puzzle you’re working on.

Mood-improving medication Crossword Answer

↓42.

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Helpful Hints

(noun)
1. an antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain

Hint 2: Clue Definitions

IMPROVING (adjective)
1. getting higher or more vigorous
MEDICATION (noun)
1. (medicine) something that treats or prevents or alleviates the symptoms of disease
2. the act of treating with medicines or remedies

Hint 3: Anagram

Unscramble the letters below to solve for today's answer.
SIRS

More Missing Letter Crossword (2/22/2026) Answers

Across

1. NOUN: "a mode or manner of looking at or regarding something"

5. NOUN: "a member of a pastoral and agricultural people who inhabit a plateau region in adjoining parts of Turkey, Iran, Iraq, Syria, Armenia, and Azerbaijan"

9. VERB: "to fall into a light sleep"

13. ADJECTIVE: "not occupied or employed"

14. NOUN: "a [written work] composed in or converted to digital format for display on a computer screen or handheld device"

16. NOUN: "a chamber (as in a stove) that is used for baking, heating, or drying"

17. ___ monster (Arizona critter)

18. Be mean to on the playground

19. Chill (out)

20. NOUN: "types of [activity] (such as music, dance, or drama) that are [exhibited to] an audience"

23. Marino in Miami

24. Tiniest bit

25. NOUN: "the manipulation of materials on an atomic or molecular scale especially to build microscopic devices (such as robots)"

33. Totally floored

34. NOUN: "any of several large strong nocturnal carnivorous Old World mammals...that usually feed as scavengers"

35. NOUN: "a shot or point in racket games that does not count and must be replayed"

37. Have ___ with (be connected to)

38. Common Mexican restaurant name

39. Tabula __: blank slate

40. Part of USSR

41. Boxer or basenji, say

42. NOUN: "a 2- or 4-door automobile seating four or more persons and usually having a permanent top"

43. NOUN: "something or someone that was popular once, but is not popular now"

46. Belonging to us both

47. It's worth more than "plata"

48. NOUN: "someone who gives unwanted advice"

56. Mine in Montreal

57. NOUN: "an ignorant, misinformed, or dishonest practitioner of medicine"

58. NOUN: "the uppermost point"

60. NOUN: "a Jewish prophet who according to Gospel accounts foretold Jesus' messianic ministry and baptized him"

61. Pizzazz

62. NOUN: "the alternate rising and falling of the surface of the ocean"

63. AL MVP of '03, '05, and '07

64. Estate recipient

65. Nobel Prize field (abbr.)

All Answers

Down

1. Bookie's take

2. "___ my toes into the sand" (Incubus lyric)

3. Magazine with a French name

4. VERB: "to...overcome by persistent resistance or pressure"

5. Kind of organic compound

6. PREFIX: "to an extreme or excessive degree"

7. Travel without a destination

8. ___-do (square-dancing move)

9. El ___ (lost city of gold)

10. Trucker's "Your turn to talk"

11. NOUN: "an enjoyably exciting quality"

12. Tolkien creatures

15. Jazzman Stan et al.

21. NOUN: "an inevitable and often adverse outcome, condition, or end"

22. NOUN: "a medium-sized apple with crisp yellowish-white sweet flesh"

25. Director DaCosta et al.

26. Irk

27. Easy to fool

28. Make noise for the team

29. Publicized aggressively

30. “I ___ vacation!”

31. Clearing in the forest

32. "not because ___ the miracles" (passage from John)

36. Gets some sun, say

38. Classes needed to take another class

39. VERB: "to [bring back] to a former better state (as by cleaning, repairing, or rebuilding)"

41. Energy amts.

44. Highly pleasant

45. "The New ___" (posh magazine)

48. Mexican peninsula

49. Love, in Latin

50. NOUN: "a rather small Pacific salmon (Oncorhynchus kisutch) that has light-colored flesh and is native to both coasts of the North Pacific and is stocked in the Great Lakes"

51. Person who wrote a book (abbr.)

52. Diggs in "How Stella Got Her Groove Back"

53. The year 651

54. Utterly amazing

55. Second try

59. COMBINING FORM: "foreign"

All Answers