Most certain Crossword Clue

We have the 6-letter answer for Most certain crossword clue, last seen in the USA Today Crossword March 22, 2026 puzzle. Let us help you solve the crossword clue that has you stumped so you can finish the puzzle.

Most certain Crossword Answer

→40.

Find more clues, hints, and info below.

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Helpful Hints

Hint 1: Clue Definitions

CERTAIN (adjective)
1. having or feeling no doubt or uncertainty; confident and assured
2. certain to occur; destined or inevitable
MOST (adverb)
1. (of actions or states) slightly short of or not quite accomplished; all but
2. used to form the superlative
MOST (adjective)
1. (superlative of `many’ used with count nouns and often preceded by `the’) quantifier meaning the greatest in number
2. the superlative of `much’ that can be used with mass nouns and is usually preceded by `the’; a quantifier meaning the greatest in amount or extent or degree

Hint 2: Anagram

Unscramble the letters below to solve for today's answer.
ESTRUS

More USA Today Crossword (3/22/2026) Answers

Across

1. 'At what time?'

5. "What's up, everyone!"

10. House cat, e.g.

13. Belgian coin

14. Come next

15. Indigenous people of northern Scandinavia

16. Shapeless thing

17. Herbivorous animal with armorlike skin

19. Pesto herb

21. Small battery type

22. Insect in a colony

23. "___ With a Pearl Earring" (Vermeer painting)

25. Added perk

28. Animal also known as a gnu

34. Western Nevada city

35. Smallest of the Great Lakes, by volume

36. Math diagram with axes

37. Waffle ___ (breakfast appliance)

38. Spanish appetizers

42. Names of books

44. Antelope that can jump up to 10 feet in the air

47. That, in Spanish

48. Rollaway bed

50. Earth-related prefix

51. Opposite of Rx

53. Auto blemish

55. Beach ball's contents

57. Peripheral

59. Region also known as the Somali Peninsula . . . or how you might describe a notable feature of 17-, 28- and 44-Across

63. Croc's relative

66. __ dive

67. Trail mix

68. Solo

69. Make tweaks to

70. Name that anagrams to a part of the face

71. Set free

72. Orpheus' instrument in "Hadestown"

73. Opposite of NNE

All Answers

Down

1. Apt last name for a spider lover

2. Dance style in "Lilo & Stitch"

3. Greek god of love

4. "That doesn't matter"

5. She/___

6. Asthma-treating devices

7. Nepal's continent

8. Name meaning "moon"

9. Summer zodiac sign

10. __ in crime

11. Genre for Paramore

12. Quaint contraction

15. Spanish term of address

18. Taxi

20. Two truths and a ___

24. "Notorious" Supreme Court initials

26. "___, dos, tres ..."

27. Orpheus, to Calliope

28. Made damp

29. "Let's make the bet even higher"

30. Pure Leaf tea maker

31. French for 'water'

32. Bit of rosemary or thyme

33. Recurring motif in a musical

39. "Hang on just a ___!"

41. Parody

43. Fly high

45. Moisturizing products

46. Dined on humble pie

49. Sparkly Christmas decoration

52. Dice-throwing casino game

54. Simple sandal type

56. Raucous

58. Impulses

60. Chocolatey churro flavor

61. Opposite of foul

62. Opening poker bet

63. Casual term for a 23-Across

64. Ginger ___

65. Tater ___

All Answers