Word that means to "make a difference" ... or when used with "white," pale tissue of the brain and spinal cord Crossword Clue

We have the 6-letter answer for Word that means to "make a difference" ... or when used with "white," pale tissue of the brain and spinal cord crossword clue, last seen in the Daily Themed Crossword December 12, 2025 puzzle. Let us help you solve the crossword clue that has you stumped so you can finish the puzzle.

Word that means to "make a difference" ... or when used with "white," pale tissue of the brain and spinal cord Crossword Answer

→21.

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Helpful Hints

(noun)
1. a vaguely specified concern
2. some situation or event that is thought about
(verb)
1. have weight; have import, carry weight

Hint 2: Clue Definitions

SPINAL (noun)
1. anesthesia of the lower half of the body; caused by injury to the spinal cord or by injecting an anesthetic beneath the arachnoid membrane that surrounds the spinal cord
DIFFERENCE (noun)
1. a variation that deviates from the standard or norm
2. the number that remains after subtraction; the number that when added to the subtrahend gives the minuend

More Daily Themed Crossword (12/12/2025) Answers

Across

1. Number that follows nine

4. Double-helix genetic material: Abbr.

7. Put money on a race, say

10. "Mi ___" (Spanish for "my love")

12. Alley-___ (NBA play)

13. King Kong, for one

14. Ballerina's costume

15. "Through thick and ___" (under all circumstances)

16. "Shop ___ You Drop" (popular game show)

17. ___-cone (cold treat)

19. Lay eyes on

24. ___ de toilette (lightly scented perfume)

25. "Four score and seven years ___..."

26. Dial-up Internet alternative Abbr.

28. Chest bones

32. “Summertime Sadness” singer ___ Del Rey

34. Opposite of "in" ... or a word with "white" to mean a dangerous weather condition when snow severely affects visibility

36. "Dedicated to the ___ Love": 2 wds.

37. ___ room (fun and activities room, informally)

38. Offer a price, at an auction

40. "The Situation Room" channel: Abbr.

41. Event hosts: Abbr.

44. Opposite of "dark" ... or a word with "white" to mean a form of electromagnetic radiation that looks colorless but contains all colors

46. Remarkable achievement (rhymes with "seat")

47. Trio after K

48. Largest association of doctors in the US: Abbr.

50. Lil Wayne's genre

52. Smallest unit of life ... or when used with "white," disease-fighting component of blood, also called a leukocyte

56. Word before "profile" or "blow"

57. X-___ large (tee size, perhaps)

58. Vowels between "a" and "u"

59. Hamlet, to Gertrude

60. "Wee" backward

61. The in French

All Answers

Down

1. Tit for __

2. Australian bird that's the world's second-largest after the ostrich

3. "___ so fast, mister!" ("Slow down!")

4. Play-___ (children's clay toy)

5. Unpleasant sound ... or a word with "white" to mean a low, humming sound that results from many combined frequencies

6. Sleep ___ (disorder that makes it hard to breathe)

7. Nocturnal mammal that hangs around in a cave

8. Prefix with "center" or "dermal"

9. Graham Bell's patent, for short

11. Sign of oxidation ... or a word with "white" to mean a fungal plant disease with white spores

15. Upper body part often depicted in sculptures

18. Father of Todd and Rod Flanders on "The Simpsons"

20. Currency in France

21. Negative prefix with "nourished" or "nutrition"

22. Gelatin in a petri dish (anagram of "raga")

23. "Don't take that ___ with me!" ("Don't speak to me like that!")

27. ___ dub (heartbeat sounds)

29. Waistline unit

30. Like one's knee when proposing

31. Sloth or gluttony, for one

33. Wile E. Coyote's TNT supplier

35. Cash register

39. ___ sum (Chinese dish)

42. À la ___ (menu option)

43. Unwavering, unblinking look

45. Health supplement chain: Abbr.

46. Young deer

48. Pacino and Gore, for two

49. Utterance from an uddered one

51. Pet’s furry foot

53. 'Slippery' swimmer

54. Make a dishonest statement, say

55. ___ Alamitos, California

All Answers