Immune system agent Crossword Clue

We have the 5-letter answer for Immune system agent crossword clue, last seen in the WSJ Crossword March 21, 2026 puzzle. This answer will help you finish the puzzle you’re working on.

Immune system agent Crossword Answer

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Helpful Hints

Hint 1: Clue Definitions

IMMUNE (adjective)
1. relating to or conferring immunity (to disease or infection)
2. secure against
IMMUNE (noun)
1. a person who is immune to a particular infection
SYSTEM (noun)
1. an ordered manner; orderliness by virtue of being methodical and well organized
2. a group of independent but interrelated elements comprising a unified whole

More WSJ Crossword (3/21/2026) Answers

Across

1. Business that can change your locks

8. Extremely untaxing, briefly

12. Bobbing on the waves

18. Tweak

19. Wintour of Condé Nast

20. Closest parking, perhaps

22. Rat

23. What element #14 is worth?

25. Prison that Johnny Cash sang about

26. Like most Gallaudet University students

28. Zesty flavor

29. Right, e.g.

30. Butterfield of “Hugo”

31. Hottie trading punches?

34. Family nickname

37. Dear, to Donatello

38. "Gave it my best shot"

41. Serial fabulist

43. 'How's it goin'?'

45. Beaver unable to speak?

49. Corruption catcher

51. Meaningless

54. Summer’s result

55. Evasive move on the ice

56. Load-bearing machines

58. Cuatro doubled

60. Edit, say

62. Turmoil between the Hatfields and McCoys?

65. Bus. ender

66. Pointer’s pointer

69. Co. bailed out in 2008

70. Reacts to a missed call

71. It might make you see some unbelievable things

72. Gin-flavoring fruit

73. News agcy. since 1958

74. General who’s part of many orders

75. Recede

76. Church seating for a couple of whales?

79. "The Art of Fugue" composer

81. Place to get cheap drinks

82. Rhetorical comparison

83. 'And another thing . . .'

86. Predecessor of Messages, on Macs

88. Slinger of youthspeak, typically

90. Selects carefully

91. Harpoon

94. Punch sound

96. Sticky situation

97. Shower cleaner

98. Grammarian’s concern

101. Tower setting

103. Thickness

104. Alternative timeline that hasn’t happened yet?

108. Polar toiler

111. Mother of Castor and Pollux

113. Staten Island, e.g., informally

114. Miles away

115. Senator Mazie Hirono’s state

117. Celebration for a homeowner whose house is glowing?

120. Parts of some gorilla costumes

122. Extremely slow

123. County Wicklow land

124. Budgerigar, e.g.

125. Takes on

126. Skeleton need

127. High-minded folks?

All Answers

Down

1. Boozehounds

2. Small imported car of the ’80s, made much bigger?

3. Bygone GM compacts

4. Disco gizmo

5. Collectible German figurines

6. What I stood for in ancient times

7. Pain ___ (French toast, to the French)

8. Sweet melon

9. Military outfit

10. Most Emmy-winning show of all time

11. Hispaniola half

12. Included in

13. Big canine

14. Tyler of "Ad Astra"

15. Spouting off

16. Making subtle references

17. Play around

18. World Cup org.

21. Bill depicting the U.S. Treasury

24. Give the boot to

27. “Need I continue?” letters

32. Target of donation requests

33. Strike

34. Honorific for Jeanne d’Arc

36. Got all misty

38. Senator Tammy Duckworth’s state

39. Spider sighter’s squeal

40. N.W.A co-founder, casually

41. Butter or lard, to a dieter

42. "No kidding!"

44. Magic show sound effects

46. Rishi Sunak, e.g.

47. Season in Soissons

48. Makes petty objections

50. Apache and Arapaho

52. Text-scanning tech, for short

53. “Gossip Girl” airer

57. High-and-mighty

59. “Cross my heart,” in modern slang

61. Perfect for postcards, say

63. Head home

64. Shush!

66. Teacher who makes the class happy?

67. Famed Harlem theater

68. Like Houston’s Katy Freeway, of all U.S. roads

72. Take all the games in a series

76. Lose one’s cool, perhaps?

77. Leading woman?

78. Coax a laugh from

79. MVP quarterback in 2013’s Super Bowl

80. Michael of 10-Down

83. Saddler's tool

84. Luang Prabang language

85. Come to a complete halt

87. Chinese rival of Amazon

89. Chef Matsuhisa with a namesake restaurant chain

92. Starfish arm

93. Cole Porter song

95. Bronze Star honoree

99. Ruffle

100. Singer Lipa

102. Macho admonition

104. Is plenty angry

105. Middle-earth meanie

106. Poet Alfred

107. Critter catchers

109. Is fond of

110. Thing to bump or pump

111. Race segment

112. Jazzy Fitzgerald

113. Rotten tot

116. Come to

118. Pro’s advice

119. Link that might be broken

121. Butter bit

All Answers